RBN-2397,CAS#2381037-82-5

Name O=C1C(C(F)(F)F)=C(N[C@@H](C)COCCC(N2CCN(C3=NC=C(C(F)(F)F)C=N3)CC2)=O)C=NN1
copyRight
Molecular Structure
Molecular Formula C20H23F6N7O3
Molecular Weight 523.43
CAS Registry Number 2381037-82-5

RBN-2397 is a potent, accross species and orally active NAD+ competitive inhibitor of PARP7 (IC50<3 nM). RBN-2397 selectively binds to PARP7 (Kd=0.001 μM) and restores interferon (Type I) signaling. RBN-2397 has the potential for the study of advanced or metastatic solid tumors.

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