CAS No. 2095719-92-7 Cat. No. BCP32082
Name ASTX-029
Synonyms ASTX 029;ASTX 029;ERK1/2 inhibitor 2;
Chemical Name
Formula C29H31ClFN5O5 M. Wt 584.04
Purity 98% Storage Store at 4-8°C
Description ASTX029 is a synthetic small molecule inhibitor of extracellular signal-regulated kinases (ERKs) 1/2. ASTX029 has not been previously evaluated in human subjects. The Phase 1 portion of this study will assess safety and determine the maximum tolerated dose, the recommended Phase 2 dose (RP2D), and the recommended dosing regimen of ASTX029 administered orally. The Phase 2 portion will assess preliminary clinical activity in tumors characterized by gene aberrations in the mitogen-activated protein kinase (MAPK) signal pathway that may confer sensitivity to ASTX029.

Leave a Reply