SBI-0206965,CAS#1884220-36-3
CAS No. 1884220-36-3 Cat. No. BCP29511
Name SBI-0206965
Synonyms SBI0206965; SBI 0206965;
SMILES O=C(NC)C1=CC=CC=C1OC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Br
Chemical Name
Formula C21H21BrN4O5 M. Wt 489.32
Purity 98% Storage Store at 4-8°C
Description SBI0206965 is a potent and selective autophagy Kinase ULK1 Inhibitor. Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy as a potential broadly applicable cancer therapy. SBI-0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI-0206965 greatly synergized with mechanistic target of rapamycin (mTOR) inhibitors to kill tumor cells, providing a strong rationale for their combined use in the clinic.